Richard-Lenoble D, Kombila M, Chandenier J, Gaxotte P
Departement de Parasitologie-Mycologie-Médecine tropicale, Centre Universitaire des Sciences de la Santé (CUSS), Libreville, Gabon.
Bull Soc Pathol Exot Filiales. 1989 Jan;82(1):65-71.
Administration of ivermectin (Mectizan) in Loa loa filariasis induces a significant decrease of microfilaria load within 3 to 15 days. The excellent tolerability of the drug in patients infested simultaneously by O. volvulus and Loa loa allows to use ivermectin in mass treatments in geographical areas where the same patients can be affected by several filariasis. There is almost no efficacy against Mansonella perstans. A second administration one month after the first one in Loa loa affected patients has not led to a complete disappearance of microfilaria; the tolerability has still been good. Efficacy on Ascaris lumbricoides appears to be excellent; further studies are necessary in the cases of trichuriasis, ancylostomiasis and strongyloidiasis.
在罗阿丝虫病中使用伊维菌素（美迪善）可在3至15天内使微丝蚴负荷显著降低。该药物对同时感染盘尾丝虫和罗阿丝虫的患者具有良好的耐受性，这使得在同一患者可能受到多种丝虫病影响的地理区域可以使用伊维菌素进行群体治疗。对常现曼森线虫几乎没有疗效。在感染罗阿丝虫的患者中，首次用药一个月后再次给药并未使微丝蚴完全消失；耐受性仍然良好。对蛔虫的疗效似乎极佳；对于鞭虫病、钩虫病和类圆线虫病，还需要进一步研究。
