Roux J, Perolat P, Cartel J L, Boutin J P, Sechan Y, Larivière M, Aziz M A
Institut territorial de recherches médicales Louis-Malardé, Papeete, Tahiti.
Bull Soc Pathol Exot Filiales. 1989 Jan;82(1):72-81.
Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.
