Reizenstein P, Mathé G
Bull Soc Sci Med Grand Duche Luxemb. 1989 Mar-Apr;126(1):57-8.
If Skipper's exponential growth and 'log-kill' hypothesis is replaced by one assuming an S-shaped growth curve and a growth inhibition proportional to the product of the growth fraction and the tumor volume, little growth inhibition can be achieved in minimal tumors. This 'kinetic refractoriness' may explain why minimal residual tumors cannot be eradicated by adjuvant chemotherapy.
如果将斯基珀的指数生长和“对数杀伤”假说替换为假设呈S形生长曲线且生长抑制与生长分数和肿瘤体积的乘积成比例的假说，那么在微小肿瘤中几乎无法实现生长抑制。这种“动力学难治性”可能解释了为什么辅助化疗无法根除微小残留肿瘤。
