Chen Yi-Chun, Huang Yu-Li, Ho Wen-Chao, Wang Yu-Chun, Yu Yang-Hao
a Department of Health Management , I-Shou University , Kaohsiung , Taiwan.
b Department of Safety, Health and Environmental Engineering , National Kaohsiung First University of Science and Technology , Kaohsiung , Taiwan.
J Asthma. 2017 Apr;54(3):279-285. doi: 10.1080/02770903.2016.1212367. Epub 2016 Jul 19.
To investigate lung function associated with asthma and body mass index (BMI) among adolescents at 96 northern Taiwan junior high schools participating in an asthma screening program.
The questionnaires and lung function test results measured for 3669 boys and 3523 girls were included in this study for data analysis. Measures of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV) and FEV/FVC ratio were compared by sex, asthma status and BMI.
Overall mean FVC levels were similar between students with and without asthma, 3.71 L vs. 3.71 L for boys (p = 0.991) and 2.79 vs. 2.78 for girls (p = 0.517). The overall mean FEV levels were also similar between girls with and without asthma. Asthmatic boys had lower FEV than non-asthmatic boys. Mean FEV/FVC was significantly lower in students with asthma than those without asthma. Mean FVC and FEV increased with BMI in both sexes. A lower mean FEV/FVC was observed among students with asthma and high BMI, and was more pronounced in boys than in girls. Multivariable regression analysis also showed that FEV/FVC ratios were negatively associated with asthma and high BMI, stronger in boys than in girls for asthma (β = -2.176 (standard errors (SE) = 0.268) vs. -1.085 (SE = 0.258) and for BMI (β = -0.309 (SE = 0.025) vs. -0.218 (SE = 0.029)).
This northern Taiwan study suggests that FEV/FVC is negatively associated with asthma and high BMI in adolescents, stronger for boys than for girls.
在参与哮喘筛查项目的96所台湾北部初中的青少年中，调查与哮喘及体重指数（BMI）相关的肺功能。
本研究纳入了3669名男生和3523名女生的问卷及肺功能测试结果进行数据分析。通过性别、哮喘状况和BMI比较用力肺活量（FVC）、第1秒用力呼气量（FEV）和FEV/FVC比值的测量值。
有哮喘和无哮喘的学生总体平均FVC水平相似，男生分别为3.71升和3.71升（p = 0.991），女生分别为2.79升和2.78升（p = 0.517）。有哮喘和无哮喘的女生总体平均FEV水平也相似。哮喘男生的FEV低于非哮喘男生。哮喘学生的平均FEV/FVC显著低于无哮喘的学生。男女两性的平均FVC和FEV均随BMI增加。哮喘且BMI高的学生中观察到较低的平均FEV/FVC，且在男生中比在女生中更明显。多变量回归分析还显示，FEV/FVC比值与哮喘和高BMI呈负相关，哮喘方面在男生中比在女生中更强（β = -2.176（标准误（SE） = 0.268）对 -1.085（SE = 0.258）），BMI方面也是如此（β = -0.309（SE = 0.025）对 -0.218（SE = 0.029））。
这项台湾北部的研究表明，青少年中FEV/FVC与哮喘和高BMI呈负相关，在男生中比在女生中更强。
