Li Peng, Yang Xiao-Ke, Wang Xiu, Zhao Meng-Qin, Zhang Chao, Tao Sha-Sha, Zhao Wei, Huang Qing, Li Lian-Ju, Pan Hai-Feng, Ye Dong-Qing
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, Anhui, PR China; ZhouShan Municipality Center for Disease Control and Prevention, Zhoushan, PR China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, Anhui, PR China.
Hum Immunol. 2016 Oct;77(10):990-996. doi: 10.1016/j.humimm.2016.07.008. Epub 2016 Jul 18.
Both Crohn's disease (CD) and ulcerative colitis (UC) have a complex etiology involving multiple genetic and environmental factors. Multiple UC and CD susceptibility genes have been identified through genome-wide association studies and subsequent meta-analyses. The aim of this meta-analysis was to clarify the impact of MYO9B gene polymorphisms on CD and UC risk.
The PubMed, Elsevier Science Direct and Embase databases were searched to identify eligible studies that were published before October 2014. Data were extracted and pooled crude odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
A total of 11 studies, containing 3297 CD cases, 3903 UC cases and 8174 controls were included in this meta-analysis. Bonferroni correction results showed that rs1545620 A/C polymorphism of MYO9B gene was associated with both CD and UC susceptibility in Caucasians (OR=0.88, 95% CI=0.82∼0.95, P=0.001; OR=0.82, 95% CI=0.76∼0.89, P<0.001), but not in Chinese. rs1457092 G/T and rs2305764 C/T polymorphisms are associated with UC susceptibility (OR=0.85, 95% CI=0.79∼0.91, P<0.001; OR=0.88, 95% CI=0.83∼0.93, P<0.001), but not with CD susceptibility in Caucasians.
This meta-analysis suggested that rs1545620 is both CD and UC susceptible locus in Caucasians; rs1457092 and rs2305764 are UC susceptible loci, but are not CD susceptible loci in Caucasians. Further studies with more sample size are needed for a definitive conclusion.
克罗恩病（CD）和溃疡性结肠炎（UC）均具有涉及多种遗传和环境因素的复杂病因。通过全基因组关联研究及后续的荟萃分析，已鉴定出多个UC和CD易感基因。本荟萃分析的目的是阐明MYO9B基因多态性对CD和UC发病风险的影响。
检索PubMed、Elsevier Science Direct和Embase数据库，以识别2014年10月之前发表的符合条件的研究。提取数据并汇总计算粗比值比（OR）和95%置信区间（95%CI）。
本荟萃分析共纳入11项研究，包含3297例CD病例、3903例UC病例和8174例对照。Bonferroni校正结果显示，MYO9B基因的rs1545620 A/C多态性与白种人中CD和UC的易感性均相关（OR = 0.88，95%CI = 0.82∼0.95，P = 0.001；OR = 0.82，95%CI = 0.76∼0.89，P < 0.001），但在中国人中无此关联。rs1457092 G/T和rs2305764 C/T多态性与UC易感性相关（OR = 0.85，95%CI = 0.79∼0.91，P < 0.001；OR = 0.88，95%CI = 0.83∼0.93，P < 0.001），但与白种人中的CD易感性无关。
本荟萃分析表明，rs1545620是白种人中CD和UC的易感位点；rs1457092和rs2305764是UC的易感位点，但不是白种人中CD的易感位点。需要进一步开展更大样本量的研究以得出确切结论。
