Ito Y, Noda H, Isaka M, Ando K, Sato Y, Fujita T
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Clin Exp Hypertens A. 1989;11 Suppl 1:363-70. doi: 10.3109/10641968909045442.
The pressor effects of intravenous norepinephrine (NE) infusion (100 and 200 ng/kg/min for 15 min) were examined in 17 patients with borderline hypertension (BHT) and 15 age-matched normotensive subjects (NT) under three different sodium balances; the regular customary diet, treatment with diuretics, and the high-sodium diet. Treatment with diuretics decreased and high sodium diet increased the pressor response to NE in both groups but there were no significant differences in NE reactivity between the groups. The increments in mean blood pressure after NE infusion (200 ng/kg/min) during the three experimental periods correlated significantly with the preinfusion plasma NE concentration in both BHT and NT: r = -0.58 (p less than 0.01) and r = -0.54 (p less than 0.01), respectively. Neither the slopes nor the intercepts differed between the two groups. Thus, evidence presented indicates that BHT do not have increased pressor responsiveness to NE, and that NE pressor response depends upon basal sympathetic tone.
在17例临界高血压（BHT）患者和15例年龄匹配的血压正常受试者（NT）中，于三种不同钠平衡状态下，即常规习惯饮食、利尿剂治疗以及高钠饮食时，检测静脉输注去甲肾上腺素（NE）（100和200 ng/kg/分钟，共15分钟）的升压效应。利尿剂治疗使两组对NE的升压反应降低，高钠饮食则使其升高，但两组之间NE反应性无显著差异。在三个实验阶段中，输注NE（200 ng/kg/分钟）后平均血压的升高在BHT组和NT组均与输注前血浆NE浓度显著相关：分别为r = -0.58（p < 0.01）和r = -0.54（p < 0.01）。两组之间的斜率和截距均无差异。因此，现有证据表明，BHT患者对NE的升压反应性并未增加，且NE升压反应取决于基础交感神经张力。
