Esler M, Lambert G, Jennings G
Baker Medical Research Institute, Prahran, Australia.
Clin Exp Hypertens A. 1989;11 Suppl 1:75-89. doi: 10.3109/10641968909045414.
Overall and regional rates of norepinephrine overflow to plasma were measured in 55 untreated patients with primary hypertension and in 40 healthy subjects, to study sympathetic nervous pathophysiology in human hypertension. Total norepinephrine spillover was increased in primary hypertension, particularly in patients aged less than 40 years, largely due to higher rates of renal and cardiac norepinephrine overflow. Renal renin release, and arterial plasma renin activity, were highest in these younger patients with increased renal sympathetic nervous activity. In older patients sympathetic activity and norepinephrine release was typically normal. A selective increase in the sympathetic nervous outflow to the heart and kidneys is commonly present in young patients with primary hypertension, and probably contributes materially to the early pathogenesis of the hypertension.
为研究人类高血压中的交感神经病理生理学，对55例未经治疗的原发性高血压患者和40名健康受试者测定了去甲肾上腺素向血浆中的总体溢出率和局部溢出率。原发性高血压患者的总去甲肾上腺素溢出增加，尤其是40岁以下的患者，这主要是由于肾脏和心脏的去甲肾上腺素溢出率较高。在这些肾脏交感神经活动增加的年轻患者中，肾脏肾素释放和动脉血浆肾素活性最高。在老年患者中，交感神经活动和去甲肾上腺素释放通常正常。原发性高血压年轻患者中常见心脏和肾脏交感神经输出选择性增加，这可能在很大程度上促成了高血压的早期发病机制。
