托吡酯的表型评估与发现
Phenotypic Assessment and the Discovery of Topiramate.
作者信息
Maryanoff Bruce E
机构信息
Baruch S. Blumberg Institute , 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
出版信息
ACS Med Chem Lett. 2016 Jun 13;7(7):662-5. doi: 10.1021/acsmedchemlett.6b00176. eCollection 2016 Jul 14.
Abstract
The role of phenotypic assessment in drug discovery is discussed, along with the discovery and development of TOPAMAX (topiramate), a billion-dollar molecule for the treatment of epilepsy and migraine.
摘要
本文讨论了表型评估在药物发现中的作用，以及妥泰（托吡酯）的发现与开发过程。妥泰是一种用于治疗癫痫和偏头痛的价值十亿美元的药物。
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