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皮下脂膜炎样T细胞淋巴瘤：一种罕见肿瘤。

Subcutaneous Panniculitis-Like T-Cell Lymphoma: A Rare Tumour.

作者信息

Bhojaraja Mohan Varadanayakanahalli, Kistampally Pradeep Kumar Reddy, Udupa Karthik S, Thomas Joseph

机构信息

Senior Resident, Department of Medicine, Kasturba Medical College and Hospital , Manipal, Karnataka, India .

Junior Resident, Department of Medicine, Kasturba Medical College & Hospital , Manipal, Karnataka India .

出版信息

J Clin Diagn Res. 2016 May;10(5):OD29-30. doi: 10.7860/JCDR/2016/18458.7824. Epub 2016 May 1.

DOI:10.7860/JCDR/2016/18458.7824
PMID:27437288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4948464/
Abstract

Subcutaneous Panniculitis like T cell Lymphoma (SPTCL) is an uncommon variant and poorly differentiated type of cutaneous T cell lymphoma. Here we describe the case of a 19-year-old female who presented with swelling of left half of the face with no regional lymphadenopathy and hepatosplenomegaly which was initially misdiagnosed as a benign cutaneous condition by various practitioners. Histopathological examination revealed diffuse infiltration of subcutaneous plane by small to medium sized atypical lymphocytes. Immunohistochemistry showed CD3, CD8 and βF-1 positivity; CD20, CD56, Epstein Barr Virus (EBV) and TCR-δ negativity. Clinical profile, histopathology and immunohistochemical analysis yielded a diagnosis of SPTCL. Thus cases with atypical and nonresolving dermatological lesions should raise a suspicion of SPTCL as diagnosis against other benign conditions.

摘要

皮下脂膜炎样T细胞淋巴瘤（SPTCL）是一种罕见的、低分化型皮肤T细胞淋巴瘤。在此，我们描述了一名19岁女性的病例，该患者左脸肿胀，无区域淋巴结肿大及肝脾肿大，最初被多名医生误诊为良性皮肤疾病。组织病理学检查显示皮下组织有中小等大小非典型淋巴细胞弥漫浸润。免疫组化显示CD3、CD8和βF-1阳性；CD20、CD56、爱泼斯坦-巴尔病毒（EBV）和TCR-δ阴性。临床特征、组织病理学和免疫组化分析得出SPTCL的诊断。因此，对于具有非典型且不消退的皮肤病变的病例，应怀疑为SPTCL，以便与其他良性疾病进行鉴别诊断。

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本文引用的文献

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Acta Med Iran. 2014;52(12):950-3.
2
Positron emission tomography in subcutaneous panniculitis-like T-cell lymphoma.正电子发射断层扫描在皮下脂膜炎样T细胞淋巴瘤中的应用
Pediatr Blood Cancer. 2009 Mar;52(3):406-8. doi: 10.1002/pbc.21805.
3
Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases.皮下脂膜炎样T细胞淋巴瘤：定义、分类及预后因素：欧洲癌症研究与治疗组织皮肤淋巴瘤研究组对83例病例的研究
Blood. 2008 Jan 15;111(2):838-45. doi: 10.1182/blood-2007-04-087288. Epub 2007 Oct 12.
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The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants.世界卫生组织-欧洲癌症研究与治疗组织关于皮肤淋巴瘤的新分类：两大巨头的完美结合。
Br J Dermatol. 2005 Nov;153(5):874-80. doi: 10.1111/j.1365-2133.2005.06905.x.
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Fatal subcutaneous panniculitis-like T-cell lymphoma with interface change and dermal mucin, a dead ringer for lupus erythematosus.伴有界面改变和真皮粘蛋白的致死性皮下脂膜炎样T细胞淋巴瘤，酷似红斑狼疮。
J Cutan Pathol. 2005 May;32(5):360-5. doi: 10.1111/j.0303-6987.2005.00331.x.
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