对埃塞俄比亚铁角蕨（Burm. f.）贝歇勒的抗氧化、杀幼虫和细胞毒性研究。
Antioxidant, Larvicidal, and Cytotoxic Studies on Asplenium aethiopicum (Burm. f.) Becherer.
作者信息
Marimuthu Alias Antonysamy Johnson, Janarthanan Gowtham, Arumugam Sivaraman, Narayanan Janakiraman, Mani Narayani
机构信息
Centre for Plant Biotechnology, Department of Botany, St. Xavier's College (Autonomous), Palayamkottai, Tamil Nadu 627 002, India.
出版信息
Int Sch Res Notices. 2014 Aug 26;2014:876170. doi: 10.1155/2014/876170. eCollection 2014.
The present study was intended to determine the antioxidant, larvicidal, and cytotoxic potential of various extracts of Asplenium aethiopicum (Burm. f.) Becherer. Antioxidant potential of the extracts was determined by the DPPH radical scavenging, phosphomolybdenum, and scavenging of H2O2. Larvicidal activity of Asplenium aethiopicum was performed against the fourth instar larvae Culex quinquefasciatus. Cytotoxic activity was analysed in terms of brine shrimp lethality bioassay. The best free radical scavenging activity was exerted by methanolic extract of Asplenium aethiopicum (IC50 91.4 μg/mL) followed by acetone extract (IC50 99.8 μg/mL). Highest larval mortality was observed in the crude acetone extracts of Asplenium aethiopicum against Culex quinquefasciatus (LC50 = 166.6 ppm) followed by methanolic extracts. Acetone extract of Asplenium aethiopicum was found to be most effective at which 50% and 90% mortality of brine shrimp nauplii that occurred were found to be 192.8 and 434.3 ppm, respectively. The results of the present study revealed the antioxidant, larvicidal, and cytotoxic potential of Asplenium aethiopicum.
本研究旨在测定南非铁角蕨（Asplenium aethiopicum (Burm. f.) Becherer）各种提取物的抗氧化、杀幼虫和细胞毒性潜力。通过DPPH自由基清除法、磷钼法和H2O2清除法测定提取物的抗氧化潜力。对南非铁角蕨针对致倦库蚊（Culex quinquefasciatus）四龄幼虫进行杀幼虫活性测试。通过卤虫致死生物测定法分析细胞毒性活性。南非铁角蕨的甲醇提取物表现出最佳的自由基清除活性（IC50为91.4μg/mL），其次是丙酮提取物（IC50为99.8μg/mL）。观察到南非铁角蕨的粗丙酮提取物对致倦库蚊的幼虫死亡率最高（LC50 = 166.6ppm），其次是甲醇提取物。发现南非铁角蕨的丙酮提取物最有效，卤虫无节幼体50%和90%死亡率分别为192.8和434.3ppm。本研究结果揭示了南非铁角蕨的抗氧化、杀幼虫和细胞毒性潜力。
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