Kuklina E M
Institute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, Perm, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(5):102-105. doi: 10.17116/jnevro201611651102-105.
Melatonin is one of the most multifunctional regulators in the organism. It plays a key role in the control of nerve, endocrine, and immune systems. Due to hormone neuroprotective activity, the possibility is now discussed on its clinical usage in treating neurodegenerative diseases, including multiple sclerosis. At the same time, melatonin is an effective regulator of immune reactions, in part, the reactions toward autoantigens. In this respect, the subset ofT lymphocytes producing IL-17 (Th17) is of special interest. As the Th17 subset plays a key role iri multiple sclerosis pathogenesis, the immunomodulating hormone effects toward Th17, may, in theory, nullify its positive neuroprotective activity.
褪黑素是机体中功能最为多样的调节因子之一。它在神经、内分泌和免疫系统的调控中发挥着关键作用。鉴于其激素的神经保护活性，目前正在探讨其在治疗包括多发性硬化症在内的神经退行性疾病中的临床应用可能性。同时，褪黑素是免疫反应的有效调节因子，部分是对自身抗原的反应。在这方面，产生白细胞介素-17（Th17）的T淋巴细胞亚群特别受关注。由于Th17亚群在多发性硬化症发病机制中起关键作用，理论上免疫调节激素对Th17的作用可能会抵消其积极的神经保护活性。
