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Sustained static stress-induced chondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms.

作者信息

Zhang Ming, Zheng Tiansheng, Zong Min, Kong Dechao, Li Xiang, Xue Cheng, Fu Peng, Fang Jiahu

机构信息

Department of Emergency, Taizhou People's Hospital, 210 Yingchun Road, Taizhou, Jiangsu Province, 225300, People's Republic of China.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.

出版信息

Eur J Orthop Surg Traumatol. 2014 Jul;24(Suppl 1):299-304. doi: 10.1007/s00590-013-1297-8. Epub 2013 Aug 20.

DOI:10.1007/s00590-013-1297-8
PMID:27439006
Abstract

Apoptosis of the vertebral growth plate chondrocytes plays an important role in the pathogenesis of intervertebral disk degeneration. In this paper, we have successfully established an experimental model induced by static stress and provided a useful method to study the mechanisms of chondrocyte apoptosis. A sustained static load of ≥0.2 MPa over at least 12 h was observed to induce chondrocyte apoptosis, up-regulation of bax and caspase-3 expression, and down-regulation of bcl-2 expression.

摘要

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2
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本文引用的文献

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Pathological studies of intervertebral discs.
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Influence of mechanical stress on cell viability.机械应力对细胞活力的影响。
Biorheology. 2006;43(3,4):371-5.
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Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes.细胞因子、肿瘤坏死因子-α和白细胞介素-1β对骨关节炎中培养的人软骨细胞凋亡有不同的调节作用。
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Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study.机械应力诱导器官培养的小鼠椎间盘终板软骨细胞凋亡：一项体外研究
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The Bcl2 family: regulators of the cellular life-or-death switch.Bcl2家族：细胞生死开关的调节因子。
Nat Rev Cancer. 2002 Sep;2(9):647-56. doi: 10.1038/nrc883.
9
Cartilage viability after repetitive loading: a preliminary report.重复负荷后软骨的活力：初步报告。
Osteoarthritis Cartilage. 2002 Jan;10(1):71-81. doi: 10.1053/joca.2001.0483.
10
The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc.终板软骨细胞凋亡与椎间盘老化和退变之间的关系。
Spine (Phila Pa 1976). 2001 Nov 15;26(22):2414-20. doi: 10.1097/00007632-200111150-00004.