[The effect of prostaglandin inhibition with indomethacin on thrombocytopoiesis in rats].

The influence of prostaglandin deficit after treatment with indomethacin was studied on thrombocytopoiesis of rats. There was a considerable inhibition of megakariocytopoesis as well as reduction in peripheral thrombocytes, while plasmic thrombocytopoietic activity was increased. It is assumed that prostaglandin deficit affects megakaryocytopoiesis not for lack of thrombocytopoetin, but probably by inhibiting directly proliferation and differentiation of megakaryocytes and their precursors in the bone-marrow. Prostaglandins deficit does not hinder the increase of thrombocytopoetin, but when such conditions are present the retardation of megakaryocates and thrombocytes occur by the mechanism of feed back negative relationship.