McLaughlin Linda M, Gardener Glenn J
Department of Neonatology, Mater Mothers' Hospital, South Brisbane, Queensland, Australia.
Department of Paediatrics and Child Health, The University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia.
J Paediatr Child Health. 2016 Jul;52(7):722-7. doi: 10.1111/jpc.13210.
The aim of this study was to determine neonatal outcomes in pregnancies complicated by prelabour rupture of membranes (PROM) before 24 weeks' gestation.
We performed a retrospective review of medical records over a 5-year period (2007-2011) at Mater Health Services, South Brisbane, Australia. Data relating to the antenatal and perinatal course of pregnancies complicated by PROM before 24 weeks' gestation were collected. Data were also collected on neonatal diagnoses, management and outcomes for all liveborn infants resulting from these pregnancies.
One hundred and six pregnancies were complicated by PROM before 24 weeks' gestation. Thirty-three (31%) of these pregnancies resulted in delivery at pre-viable gestations (<23 weeks). There were 36 (37%) infants who survived to hospital discharge. At discharge, 47% of infants had chronic lung disease, with 81% of this group requiring supplemental oxygen at home.
Almost one-third of pregnancies complicated by PROM before 24 weeks resulted in pre-viable preterm delivery. In pregnancies continuing to a viable gestation, there remained a significant risk of neonatal mortality and morbidity, primarily due to respiratory disease.
本研究旨在确定妊娠24周前发生胎膜早破（PROM）的妊娠的新生儿结局。
我们对澳大利亚南布里斯班 Mater Health Services 在5年期间（2007 - 2011年）的病历进行了回顾性研究。收集了与妊娠24周前发生胎膜早破的妊娠的产前和围产期过程相关的数据。还收集了这些妊娠所分娩的所有活产婴儿的新生儿诊断、管理和结局的数据。
106例妊娠在24周前发生胎膜早破。其中33例（31%）妊娠在未达到存活孕周（<23周）时分娩。有36例（37%）婴儿存活至出院。出院时，47%的婴儿患有慢性肺病，其中81%的婴儿在家中需要吸氧。
几乎三分之一的妊娠在24周前发生胎膜早破导致未达到存活孕周的早产。在持续至可存活孕周的妊娠中，新生儿死亡和发病的风险仍然很高，主要是由于呼吸系统疾病。
