Metaxas Yannis, Cathomas Richard, Mark Michael, von Moos Roger
Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland.
Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland.
Lung Cancer. 2016 Dec;102:136-138. doi: 10.1016/j.lungcan.2016.07.012. Epub 2016 Jul 14.
Malignant mesothelioma is an aggressive disease with dismal prognosis despite multimodal treatment including chemotherapy, surgery and radiotherapy. At progression it is possible to provide systemic second-line treatment but its effects are limited. Herein we report two patient cases with mesothelioma who received second-line chemotherapy with the combination of cisplatin and the novel compound lurbinectedin. The combination showed promising activity in both cases with manageable toxicity. We discuss the results of this regime in the light of historical as well as emerging data in mesothelioma.
恶性间皮瘤是一种侵袭性疾病，尽管采用了包括化疗、手术和放疗在内的多模式治疗，其预后仍很差。疾病进展时可提供全身性二线治疗，但其效果有限。在此，我们报告两例间皮瘤患者接受顺铂与新型化合物鲁比卡丁联合二线化疗的病例。该联合用药在两例患者中均显示出有前景的活性，且毒性可控。我们根据间皮瘤的既往数据以及新出现的数据讨论了该治疗方案的结果。
