Han Donghee, Lee Ji Hyun, Rizvi Asim, Baskaran Lohendran, Park Hyo Eun, Choi Su-Yeon, Chun Eun Ju, Sung Jidong, Park Sung Hak, Han Hae-Won, Min James K, Chang Hyuk-Jae, Ó Hartaigh Bríain
Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medicine, 413 E. 69th Street, New York, NY, 10021, USA.
Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Int J Cardiovasc Imaging. 2016 Oct;32(10):1587-93. doi: 10.1007/s10554-016-0944-7. Epub 2016 Jul 21.
Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60-69, 70-79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9 ± 8.2 years, and 79.7 % were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95 % CI 1.08-1.18) or 400 (OR 1.22, 95 % CI 1.13-1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95 % CI 1.19-1.69) and 1.86 (95 % CI 1.42-2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.
静息心率（RHR）升高和冠状动脉钙化（CAC）的存在与炎症活动及心血管疾病结局密切相关。然而，迄今为止，高RHR与CAC之间的关系尚未得到充分研究，尤其是在非西方人群中。因此，我们旨在研究在大量韩国成年人样本中，高RHR与通过CAC评分衡量的亚临床动脉粥样硬化负担之间的横断面关系。共有26018名受试者入组，并作为更广泛的一般健康检查的一部分接受了CAC筛查。RHR被分为四组：每分钟<60次、60 - 69次、70 - 79次和≥80次。采用多变量逻辑回归模型来估计基于RHR的CAC评分>0、>100或>400的几率。研究人群的平均年龄为53.9±8.2岁，79.7%为男性。调整后，RHR每增加每分钟10次，CAC评分高于100（比值比[OR] 1.13，95%置信区间[CI] 1.08 - 1.18）或400（OR 1.22，95% CI 1.13 - 1.31）的几率就更高。同样，调整后，与RHR<6次/分钟的人相比 RHR≥80次/分钟的人CAC >100或>400的几率分别为1.42（95% CI 1.19 - 1.69）和1.86（95% CI 1.42 - 2.47）。在一大群韩国成年人中，发现RHR升高，尤其是高于每分钟80次，与通过CAC评分测量的亚临床动脉粥样硬化的存在独立相关。
