镍催化酮与芳基三甲基铵三氟甲磺酸盐的α-芳基化反应。
Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates.
作者信息
Li Jing, Wang Zhong-Xia
机构信息
CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
出版信息
Org Biomol Chem. 2016 Aug 21;14(31):7579-84. doi: 10.1039/c6ob01299j. Epub 2016 Jul 22.
PMID:27443786
Abstract
Nickel-catalyzed α-arylation of ketones involving aromatic C-N cleavage has been accomplished. Intermolecular coupling of aromatic ketones with a variety of aryltrimethylammonium triflates was achieved in the presence of Ni(COD)2, IPr·HCl, and LiOBu(t), giving α-arylated ketones in reasonable to excellent yields.
摘要
实现了镍催化的涉及芳族碳 - 氮裂解的酮的α-芳基化反应。在Ni(COD)2、IPr·HCl和叔丁醇锂存在下，芳族酮与多种芳基三甲基铵三氟甲磺酸盐发生分子间偶联反应，以合理至优异的产率得到α-芳基化酮。
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