胺碘酮对离体兔心脏和主动脉的抑制作用。

Inhibitory actions of amiodarone on the isolated rabbit heart and aorta.

Raddino R, Poli E, Pelà G, Gargano M, Manca C

Cattedra di Cardiologia, Università di Brescia e di Parma, Italy.

Gen Pharmacol. 1989;20(3):313-7. doi: 10.1016/0306-3623(89)90265-6.

Abstract

The inhibitory actions of amiodarone on the isolated rabbit heart and aorta have been studied. 2. Amiodarone inhibited vasopressin- and ergonovine-induced coronary spasm, starting from a concentration of 10(-7) M which did not affect myocardial contractility to 10(-4) M, which decreased myocardial contractility. 3. Sinus node activity was largely unaffected even when the highest dose of 10(-4) M was used. 4. Amiodarone did not modify the smooth muscle contraction in rabbit aorta strips precontracted with noradrenaline or potassium. 5. Comparison with other inhibitors of the cardiovascular system (alpha- and beta-blockers, nitrates, calcium entry blockers) points out a peculiar pharmacological profile of amiodarone and indicates some doubts about its presumed anti-adrenergic properties.

摘要

已对胺碘酮对离体兔心脏和主动脉的抑制作用进行了研究。2. 胺碘酮可抑制血管加压素和麦角新碱诱导的冠状动脉痉挛，浓度从10⁻⁷M（此浓度不影响心肌收缩力）至10⁻⁴M（此浓度会降低心肌收缩力）时均有此作用。3. 即使使用最高剂量10⁻⁴M，窦房结活动也基本不受影响。4. 胺碘酮不会改变用去甲肾上腺素或钾预收缩的兔主动脉条中的平滑肌收缩。5. 与其他心血管系统抑制剂（α和β阻滞剂、硝酸盐、钙通道阻滞剂）的比较指出了胺碘酮独特的药理学特征，并对其假定的抗肾上腺素能特性提出了一些疑问。