NSUN2介导的mRNA甲基化与细胞增殖

mRNA methylation by NSUN2 in cell proliferation.

作者信息

Wang Wengong

机构信息

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China.

出版信息

Wiley Interdiscip Rev RNA. 2016 Nov;7(6):838-842. doi: 10.1002/wrna.1380. Epub 2016 Jul 22.

DOI:10.1002/wrna.1380

PMID:27444144

Abstract

Methylation is a prevalent post-transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2-mediated mRNA methylation and its implications in cell proliferation and senescence. WIREs RNA 2016, 7:838-842. doi: 10.1002/wrna.1380 For further resources related to this article, please visit the WIREs website.

摘要

甲基化是一种普遍存在的转录后修饰，几乎发生在所有RNA种类中。NSUN2是一种核仁RNA甲基转移酶，已被证明可使编码控制细胞分裂和生长停滞因子的mRNA发生甲基化，从而影响其稳定性和/或翻译。在此，作者总结了在理解NSUN2介导的mRNA甲基化及其在细胞增殖和衰老中的意义方面的最新进展。《WIREs RNA》2016年，7:838 - 842。doi:10.1002/wrna.1380 有关本文的更多资源，请访问WIREs网站。