Kim Yoo, Andrés Salazar Hernández Mario, Herrema Hilde, Delibasi Tuncay, Park Sang Won
Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Internal Medicine, School of Medicine, Kastamonu, Hacettepe University, Ankara, Turkey.
J Cell Mol Med. 2016 Aug;20(8):1561-70. doi: 10.1111/jcmm.12907.
Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.
含溴结构域蛋白7（BRD7）是含溴结构域蛋白家族的成员，其功能与多种疾病有关。我们之前已经表明BRD7在代谢过程中发挥作用。然而，BRD7缺乏对葡萄糖代谢的影响及其在体内的作用尚未完全揭示。在此，我们报告了BRD7在胚胎发育过程中的重要作用。BRD7纯合子小鼠在妊娠中期导致胚胎致死。BRD7纯合敲除（KO）小鼠表现出发育迟缓，最终所有BRD7 KO胚胎在E16.5之前在子宫内死亡。Brd7基因的部分敲低显示葡萄糖代谢有轻微变化。
