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26S蛋白酶体的生命周期：从诞生，历经调控与功能，直至消亡。

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death.

作者信息

Livneh Ido, Cohen-Kaplan Victoria, Cohen-Rosenzweig Chen, Avni Noa, Ciechanover Aaron

机构信息

Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.

出版信息

Cell Res. 2016 Aug;26(8):869-85. doi: 10.1038/cr.2016.86. Epub 2016 Jul 22.

DOI:10.1038/cr.2016.86
PMID:27444871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4973335/
Abstract

The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

摘要

26S蛋白酶体是一种大型的、约2.5兆道尔顿的多催化ATP依赖性蛋白酶复合体，它作为泛素系统的降解臂，而泛素系统是所有真核生物中细胞质、细胞核和膜蛋白调控降解的主要途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d32c/4973335/d1d8cf2b9043/cr201686f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d32c/4973335/d1d8cf2b9043/cr201686f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d32c/4973335/d1d8cf2b9043/cr201686f1.jpg

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Structure of an endogenous yeast 26S proteasome reveals two major conformational states.
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Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma.蛋白质稳态工作负荷对多发性骨髓瘤中蛋白酶体抑制剂敏感性的影响
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