Sayman Muslubas Isıl, Karacorlu Murat, Hocaoglu Mumin, Arf Serra, Ozdemir Hakan
Istanbul Retina Institute, Istanbul - Turkey.
Department of Ophthalmology, Bezmialem Vakif University, School of Medicine, Istanbul - Turkey.
Eur J Ophthalmol. 2017 Mar 10;27(2):190-195. doi: 10.5301/ejo.5000843. Epub 2016 Jul 16.
To evaluate the outcomes of transscleral diode laser photocoagulation in the eyes of children with a history of threshold retinopathy of prematurity (ROP) and compare them with the eyes of children with no or subthreshold ROP and normal term infants by spectral-domain optical coherence tomography (SD-OCT).
Three groups of children aged 4 to 10 years were included as follows: 45 patients with regressed ROP who had not received any treatment (group 1), 48 patients with a history of zone 2 threshold ROP who had been treated with transscleral diode laser (group 2), and 56 age-matched healthy full-term children (group 3). Visual acuity, refractive error, and measurement of retinal and choroidal thickness by SD-OCT were compared between groups retrospectively.
The mean gestational age (GA) and birthweight (BW) were 31 weeks and 1,409 grams in group 1, 28.7 weeks and 1,274.5 grams in group 2, and 38.4 weeks and 3,285 grams in group 3, respectively. There were 6 significant differences in the laser group: GA, BW, macular thickness, foveal depression, spherical equivalent, and visual acuity. In contrast, there were no significant differences among any of the choroidal parameters in all of the groups. Neither macular nor choroidal thickness correlated with visual acuity.
Although retinal structural changes were observed in patients with a history of ROP, especially in patients treated with laser, no significant difference was found in choroidal thickness between groups. These structural abnormalities may be related to both severity of ROP and laser treatment.
通过光谱域光学相干断层扫描（SD-OCT）评估有阈值早产儿视网膜病变（ROP）病史患儿行巩膜外二极管激光光凝术的效果，并将其与无ROP或亚阈值ROP患儿及足月正常婴儿的眼部情况进行比较。
纳入三组4至10岁儿童，如下：45例ROP已消退且未接受任何治疗的患者（第1组），48例有2区阈值ROP病史且已接受巩膜外二极管激光治疗的患者（第2组），以及56例年龄匹配的健康足月儿童（第3组）。回顾性比较三组之间的视力、屈光不正以及通过SD-OCT测量的视网膜和脉络膜厚度。
第1组的平均胎龄（GA）和出生体重（BW）分别为31周和1409克，第2组为28.7周和1274.5克，第3组为38.4周和3285克。激光治疗组有6个显著差异：GA、BW、黄斑厚度、黄斑中心凹凹陷、等效球镜度和视力。相比之下，所有组的任何脉络膜参数之间均无显著差异。黄斑厚度和脉络膜厚度均与视力无关。
尽管有ROP病史的患者，尤其是接受激光治疗的患者，观察到视网膜结构改变，但各组之间脉络膜厚度无显著差异。这些结构异常可能与ROP的严重程度和激光治疗均有关。
