三维胆管造影和瞬时弹性成像在评估囊性纤维化相关肝病中的相关性？
Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
作者信息
Lemaitre C, Dominique S, Billoud E, Eliezer M, Montialoux H, Quillard M, Riachi G, Koning E, Morisse-Pradier H, Savoye G, Savoye-Collet C, Goria O
机构信息
Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.
Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.
出版信息
Can Respir J. 2016;2016:4592702. doi: 10.1155/2016/4592702. Epub 2016 Jun 26.
Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.
背景。囊性纤维化相关肝病（CFLD）是主要死因。我们这项回顾性研究的目的是描述磁共振成像（MRI）和肝脏硬度测量（LSM）在CFLD评估中的相关性。方法。纳入所有接受MRI和LSM评估的成年囊性纤维化患者。收集门静脉高压（PHT）、肝脏形态异常或胆管炎的MR征象，LSM以kPa和梅塔维分级表示。结果。25例患者中，52%的患者MRI异常。LSM中位数为5.7 kPa（3.4 - 9.9）。3例患者为F2级，1例患者为F3级。PHT患者的LSM为7.85 kPa（3.7 - 9.9），其他患者为5（3.4 - 7.5），p = 0.02。肝功能检查异常的患者中，50%的患者LSM升高（≥F2），而肝功能检查正常的患者中94%的患者LSM正常（p = 0.04）。7例患者超声检查正常但MRI异常。结论。MRI和LSM可为CFLD提供有用信息，并可能有助于筛查PHT患者。
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