内源性大麻素系统的药理调节对阿片类药物戒断的影响：临床前动物文献综述
Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature.
作者信息
Wills Kiri L, Parker Linda A
机构信息
Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph ON, Canada.
出版信息
Front Pharmacol. 2016 Jun 28;7:187. doi: 10.3389/fphar.2016.00187. eCollection 2016.
Abstract
Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects of opiate addiction. The current review provides an overview of this literature in regards to opiate withdrawal. The opiate withdrawal syndrome, hypothesized to act as a negative reinforcer in mediating continued drug use, can be characterized by the emergence of spontaneous or precipitated aversive somatic and affective states following the termination of drug use. The behaviors measured to quantify somatic opiate withdrawal and the paradigms employed to assess affective opiate withdrawal (e.g., conditioned place aversion) in both acutely and chronically dependent animals are discussed in relation to the ability of the endocannabinoid system to modulate these behaviors. Additionally, the brain regions mediating somatic and affective opiate withdrawal are elucidated with respect to their modulation by the endocannabinoid system. Ultimately, a review of these findings reveals dissociations between the brain regions mediating somatic and affective opiate withdrawal, and the ability of cannabinoid type 1 (CB1) receptor agonism/antagonism to interfere with opiate withdrawal within different brain sub regions.
摘要
多年来，动物研究揭示了内源性大麻素系统在阿片类药物成瘾多个方面调节中的作用。本综述概述了有关阿片类药物戒断的这一文献。阿片类药物戒断综合征被认为在介导持续用药中起负性强化作用，其特征为在停药后出现自发或诱发的厌恶躯体和情感状态。本文讨论了在急性和慢性依赖动物中用于量化躯体阿片类药物戒断的测量行为以及用于评估情感阿片类药物戒断的范式（如条件性位置厌恶）与内源性大麻素系统调节这些行为的能力之间的关系。此外，还阐述了介导躯体和情感阿片类药物戒断的脑区及其受内源性大麻素系统调节的情况。最终，对这些发现的综述揭示了介导躯体和情感阿片类药物戒断的脑区之间的分离，以及1型大麻素（CB1）受体激动/拮抗作用在不同脑亚区干扰阿片类药物戒断的能力。
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Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature.内源性大麻素系统的药理调节对阿片类药物戒断的影响：临床前动物文献综述
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2
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J Pharmacol Exp Ther. 2016 May;357(2):357-66. doi: 10.1124/jpet.115.231381. Epub 2016 Mar 2.
3
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J Mol Neurosci. 2016 Apr;58(4):446-55. doi: 10.1007/s12031-016-0716-9. Epub 2016 Jan 23.
4
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