Park Jong Hoon, Pahk Kisoo, Kim Sungeun, Lim Sang Moo, Cheon Gi Jeong, Park Yeon Hee, Lee Seung-Sook, Choe Jae Gol
Musculoskeletal Oncology Clinic, Korea University Medical Center Anam Hospital, Seoul 136-705, Republic of Korea.
Department of Nuclear Medicine, Korea University Medical Center Anam Hospital, Seoul 136-705, Republic of Korea.
Oncol Lett. 2016 Aug;12(2):1620-1622. doi: 10.3892/ol.2016.4806. Epub 2016 Jun 29.
The purpose of the present study was to evaluate the fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings in patients with T-lymphoblastic lymphoma (T-LBL). In total, 9 patients with histopathologically confirmed T-LBL were included in the study. Bone marrow (BM) involvement and leukemic transformation (LT) were evaluated through iliac crest marrow biopsy and peripheral blood blast count. FDG-PET scans were performed at the initial pre-treatment point. Two experienced nuclear medicine physicians evaluated the FDG-PET images by visual analysis and using the maximum standardized uptake values (SUVmax) of the malignant lesions. Overall, 8 out 9 patients presented with BM involvement; 7 showed LT, while 1 showed BM involvement without LT. All involved T-LBL lesions were FDG-avid with variable uptake. The mean SUVmax was 6.4±3.3. T-LBL patients with BM involvement showed diffuse or nodular marrow uptake. In addition, all the patients with LT showed diffuse marrow FDG activity. However, the patient with BM involvement but no LT showed nodular FDG uptake in the marrow. In conclusion, the present study indicates that it is possible to use FDG-PET for the evaluation of the disease extent of T-LBL. Furthermore, the imaging technique could provide a diagnostic clue for determining BM involvement or LT.
本研究的目的是评估氟-18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）在T淋巴母细胞淋巴瘤（T-LBL）患者中的表现。本研究共纳入9例经组织病理学确诊的T-LBL患者。通过髂嵴骨髓活检和外周血原始细胞计数评估骨髓（BM）受累情况和白血病转化（LT）。在初始治疗前进行FDG-PET扫描。两名经验丰富的核医学医师通过视觉分析并使用恶性病变的最大标准化摄取值（SUVmax）对FDG-PET图像进行评估。总体而言，9例患者中有8例存在BM受累；7例出现LT，1例表现为BM受累但无LT。所有受累的T-LBL病变均为FDG摄取阳性，摄取程度各异。平均SUVmax为6.4±3.3。存在BM受累的T-LBL患者表现为弥漫性或结节性骨髓摄取。此外，所有出现LT的患者均表现为弥漫性骨髓FDG活性。然而，存在BM受累但无LT的患者骨髓表现为结节性FDG摄取。总之，本研究表明，FDG-PET可用于评估T-LBL的疾病范围。此外，该成像技术可为确定BM受累或LT提供诊断线索。
