Kremer B, Henne-Bruns D, Weh H J, Effenberger T
Dept. of Surgery, University of Hamburg.
Hepatogastroenterology. 1989 Feb;36(1):23-6.
Forty-two patients with advanced gastric carcinoma underwent chemotherapy in accordance with the FAMTX protocol. Complete tumor remission was achieved in 7%, and partial remission in 29% of the patients. In this group 6 patients (tumor stage: T3-4, N 2-3, M X-1) underwent a second-look operation after chemotherapy either to confirm the complete remission or the resect the remaining tumor mass. The mean follow-up time of these 6 patients is 22 (8-55) months; 4 are still in complete remission 8 to 55 months after the first operation. It is concluded that even in advanced stages of gastric carcinomas a more aggressive approach involving a combination of surgical and chemotherapeutic treatment improves the survival time of these patients.
42例晚期胃癌患者按照FAMTX方案接受化疗。7%的患者实现了肿瘤完全缓解，29%的患者实现了部分缓解。该组中有6例患者（肿瘤分期：T3 - 4，N 2 - 3，M X - 1）在化疗后接受了二次探查手术，目的是确认完全缓解或切除剩余肿瘤块。这6例患者的平均随访时间为22（8 - 55）个月；其中4例在首次手术后8至55个月仍处于完全缓解状态。结论是，即使在胃癌晚期，采用手术和化疗相结合的更积极治疗方法也能延长这些患者的生存时间。
