Campanelli Alessandra, Rendace Lidia, Parisi Francesco, D'Antonio Fabrizia, Imbriano Letizia, de Lena Carlo, Trebbastoni Alessandro
Department of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.
Department of Ophthalmology, "Sapienza" University of Rome, Rome, Italy.
Ann N Y Acad Sci. 2016 Jul;1375(1):28-37. doi: 10.1111/nyas.13155.
The aim of this study was to assess certain musical abilities in 30 patients with Alzheimer's disease (AD) and 30 healthy controls by using the complete version of the Montreal Battery of Evaluation of Amusia (MBEA). This battery evaluates melodic (scale, contour, and interval) and temporal (rhythm and meter) perception of music and musical memory. We found that altered musical processing is a common feature in AD. Despite that, AD subjects show partially spared abilities for temporal organization of music, though not for melodic perception and musical memory. This peculiar dysfunctional pattern could depend on the neurodegenerative involvement of some specific areas for music perception and memory in the brains of AD patients. Further studies are needed to investigate the usefulness of additional musical tests like the MBEA on larger samples to confirm our preliminary data.
本研究的目的是通过使用完整版的蒙特利尔失乐症评估量表（MBEA），评估30例阿尔茨海默病（AD）患者和30名健康对照者的某些音乐能力。该量表评估音乐的旋律（音阶、轮廓和音程）和时间（节奏和节拍）感知以及音乐记忆。我们发现音乐处理改变是AD的一个常见特征。尽管如此，AD患者在音乐的时间组织方面表现出部分保留的能力，不过在旋律感知和音乐记忆方面并非如此。这种特殊的功能失调模式可能取决于AD患者大脑中一些特定音乐感知和记忆区域的神经退行性病变。需要进一步的研究来调查像MBEA这样的额外音乐测试在更大样本上的有用性，以证实我们的初步数据。
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