Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland; Molecular Life Science PhD Program of the Life Science Zurich Graduate School, 8057 Zurich, Switzerland.
Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Mol Cell. 2016 Jul 21;63(2):181-183. doi: 10.1016/j.molcel.2016.07.006.
In a recent issue of Science, Gibson et al. (2016) describe an in vitro chemical genetic approach that maps the specific ADP-ribosylation sites targeted by the ADP-ribosyltransferases PARP-1, PARP-2, and PARP-3 and demonstrate that PARP-1 regulates RNA polymerase II promoter-proximal pausing.
在最近一期的《科学》杂志上，Gibson 等人（2016 年）描述了一种体外化学遗传学方法，该方法绘制了 PARP-1、PARP-2 和 PARP-3 靶向的特定 ADP-ribosylation 位点，并证明 PARP-1 调节 RNA 聚合酶 II 启动子近端暂停。
