Schraegle William A, Titus Jeffrey B
Comprehensive Epilepsy Program, Dell Children's Medical Center of Central Texas, Austin, TX, USA; Department of Educational Psychology, The University of Texas at Austin, Austin, TX, USA.
Comprehensive Epilepsy Program, Dell Children's Medical Center of Central Texas, Austin, TX, USA; Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
Epilepsy Behav. 2016 Sep;62:20-6. doi: 10.1016/j.yebeh.2016.06.006. Epub 2016 Jul 20.
Children and adolescents with epilepsy often show higher rates of executive functioning deficits and are at an increased risk of diminished health-related quality of life (HRQOL). The purpose of the current study was to determine the extent to which executive dysfunction predicts HRQOL in youth with epilepsy. Data included parental ratings on the Behavior Rating Inventory of Executive Function (BRIEF) and the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 130 children and adolescents with epilepsy (mean age=11years, 6months; SD=3years, 6months). Our results identified executive dysfunction in nearly half of the sample (49%). Moderate-to-large correlations were identified between the BRIEF and the QOLCE subscales of well-being, cognition, and behavior. The working memory subscale on the BRIEF emerged as the sole significant predictor of HRQOL. These results underscore the significant role of executive function in pediatric epilepsy. Proactive screening for executive dysfunction to identify those at risk of poor HRQOL is merited, and these results bring to question the potential role of behavioral interventions to improve HRQOL in pediatric epilepsy by specifically treating and/or accommodating for executive deficits.
患有癫痫的儿童和青少年往往表现出更高的执行功能缺陷率，且健康相关生活质量（HRQOL）下降的风险增加。本研究的目的是确定执行功能障碍在多大程度上可预测癫痫青少年的HRQOL。数据包括对130名癫痫儿童和青少年（平均年龄=11岁6个月；标准差=3岁6个月）的父母对执行功能行为评定量表（BRIEF）和儿童癫痫生活质量（QOLCE）问卷的评分。我们的结果显示近一半的样本（49%）存在执行功能障碍。BRIEF与QOLCE的幸福、认知和行为分量表之间存在中度到高度的相关性。BRIEF上的工作记忆分量表是HRQOL的唯一显著预测指标。这些结果强调了执行功能在小儿癫痫中的重要作用。对执行功能障碍进行主动筛查以识别HRQOL较差风险人群是值得的，这些结果引发了关于行为干预通过专门治疗和/或适应执行功能缺陷来改善小儿癫痫患者HRQOL的潜在作用的质疑。
