DerKinderen D J, Koten J W, Van Romunde L K, Nagelkerke N J, Tan K E, Beemer F A, Den Otter W
Pathologisch Instituut, Utrecht, The Netherlands.
Int J Cancer. 1989 Jul 15;44(1):35-9. doi: 10.1002/ijc.2910440107.
The influence of early diagnosis on sight and survival was studied in 130 patients with bilateral retinoblastoma. Nineteen patients died of this condition. Statistical analysis predicted that 12 of these 19 early deaths could have been prevented if doctors' delay had been less than 1 week. Consequently, a reduction of 65% in mortality is possible. Similarly, statistical analysis also predicted that the number of patients with resulting blindness could be reduced by 40%. Central registration and monitoring of retinoblastoma families would greatly improve early diagnosis.
对130例双侧视网膜母细胞瘤患者进行了早期诊断对视力和生存率影响的研究。19例患者死于该病。统计分析预测，如果医生的延误时间少于1周，这19例早期死亡患者中有12例可能得以避免。因此，死亡率有可能降低65%。同样，统计分析还预测，由此导致失明的患者数量可减少40%。对视网膜母细胞瘤家族进行集中登记和监测将大大改善早期诊断。
