急性精神分裂症患者血液中 DRD2、PI3KCB 和 AKT1 的 mRNA 表达。
The mRNA expression of DRD2, PI3KCB, and AKT1 in the blood of acute schizophrenia patients.
机构信息
Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.
Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China.
出版信息
Psychiatry Res. 2016 Sep 30;243:397-402. doi: 10.1016/j.psychres.2016.07.010. Epub 2016 Jul 5.
The phosphoinositide 3 kinase - protein kinase B (PI3K-Akt) signaling pathway plays an important role in the dopamine D2 receptor (DRD2) pathway and in the pathophysiology of schizophrenia. This study measured the mRNA levels of DRD2, PI3KCB, and AKT1 in peripheral blood samples from 24 acute schizophrenia patients and 20 healthy controls using real-time quantitative reverse transcription polymerase chain reaction (real-time qRT-PCR). We found that in the acute schizophrenia patients, the mRNA expression levels of DRD2 and PI3KCB were significantly lower than those in the healthy controls, while the AKT1 mRNA levels were significantly higher than those in the healthy controls. A significant relationship between the mRNA levels of DRD2 and PI3KCB was found only in the controls. In conclusion, the gene expression state of the DRD2-PI3K-AKT signaling cascade differed significantly between acute schizophrenia patients and healthy controls.
磷酸肌醇 3 激酶-蛋白激酶 B（PI3K-Akt）信号通路在多巴胺 D2 受体（DRD2）通路和精神分裂症的病理生理学中起着重要作用。本研究使用实时定量逆转录聚合酶链反应（real-time qRT-PCR）测量了 24 例急性精神分裂症患者和 20 例健康对照者外周血样本中 DRD2、PI3KCB 和 AKT1 的 mRNA 水平。我们发现，在急性精神分裂症患者中，DRD2 和 PI3KCB 的 mRNA 表达水平明显低于健康对照组，而 AKT1 的 mRNA 水平明显高于健康对照组。仅在对照组中发现 DRD2 和 PI3KCB 的 mRNA 水平之间存在显著的相关性。总之，DRD2-PI3K-AKT 信号级联的基因表达状态在急性精神分裂症患者和健康对照组之间存在显著差异。
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