Tönz O, Ramelli G P, Gebbers J O
Pädiatrische Klinik, Kinderspital Luzern.
Helv Paediatr Acta. 1989 Jun;43(5-6):539-47.
We report on a 7-year-old boy with nephrotic syndrome due to a membranous glomerulonephritis. The disease was caused by a persistent hepatitis B antigenemia without formation of antibodies. It was possible to show diffuse deposits of HBs antigen in the glomerular basement membrane and the mesangium by immunohistology. Therapy with cyclophosphamide resulted in an acute exacerbation of the hepatitis and, consequently, in a seroconversion. Subsequently, the nephrotic syndrome and the HBs antigenemia disappeared, and the hepatitis healed.
我们报告一名7岁患膜性肾小球肾炎所致肾病综合征的男孩。该疾病由持续性乙肝抗原血症且未形成抗体引起。通过免疫组织学可显示肾小球基底膜和系膜中有HBs抗原的弥漫性沉积。环磷酰胺治疗导致肝炎急性加重，进而发生血清学转换。随后，肾病综合征和HBs抗原血症消失，肝炎痊愈。
