Cyr T D, Lawrence R C, Lovering E G
Health Protection Branch, Bureau of Drug Research, Ottawa, Ontario, Canada.
J Assoc Off Anal Chem. 1989 May-Jun;72(3):436-41.
A photon correlation spectroscopy method has been developed to characterize the size distribution of fat globules in intravenous fat emulsions (IFE) in terms of mean diameter, standard deviation of the distribution, and percentage of large particles outside the distribution. Mean fat globule diameters of samples of all IFE products available in Canada were about 0.3 microns, similar to values reported in the literature. The methodology is sufficiently sensitive to detect the presence of 5% by weight of 2 microns polystyrene microspheres in an intravenous fat emulsion. The effect of changes in instrument settings and variables on the results has been evaluated.
已开发出一种光子相关光谱法，用于根据平均直径、分布的标准偏差以及分布外大颗粒的百分比来表征静脉脂肪乳剂（IFE）中脂肪球的大小分布。加拿大市场上所有IFE产品样品的平均脂肪球直径约为0.3微米，与文献报道的值相似。该方法足够灵敏，能够检测到静脉脂肪乳剂中5%（重量）的2微米聚苯乙烯微球的存在。已评估了仪器设置和变量变化对结果的影响。
