Sarkisian Alexander M, Andalib Iman, Kumta Nikhil A, Sharaiha Reem Z
Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Curr Opin Gastroenterol. 2016 Sep;32(5):353-357. doi: 10.1097/MOG.0000000000000300.
Radiofrequency ablation (RFA) has been recognized for its potential in palliative treatment for pancreatic cancer as well as malignant biliary strictures. The purpose of this review is to describe the technology, endoscopic technique, and reported outcomes of endoscopic RFA in the management of malignant biliary strictures and unresectable pancreatic cancer.
Intraductal biliary RFA is safe and feasible and appears to confer a survival advantage. Pancreatic endoscopic ultrasound-guided RFA is a promising new technique and may result in either resolution of tumor or reduction in size.
Intraductal biliary RFA and pancreatic endoscopic ultrasound-guided RFA are important modalities in malignant biliary obstruction and unresectable pancreatic cancer. Intraductal biliary RFA should be used as an adjunct to biliary stenting. Further trials are needed to determine if RFA leads to a benefit in pancreatic cancer treatment. Two prospective trials are currently underway to determine if intraductal biliary RFA indeed confers a survival advantage in malignant obstruction.
射频消融术（RFA）在胰腺癌及恶性胆管狭窄的姑息治疗中的潜力已得到认可。本综述旨在描述内镜下RFA在治疗恶性胆管狭窄和不可切除胰腺癌中的技术、内镜技术及报告的治疗结果。
胆管内RFA安全可行，似乎具有生存优势。胰腺内镜超声引导下RFA是一项有前景的新技术，可能使肿瘤消退或缩小。
胆管内RFA和胰腺内镜超声引导下RFA是治疗恶性胆管梗阻和不可切除胰腺癌的重要方式。胆管内RFA应用于胆管支架置入术的辅助治疗。需要进一步试验来确定RFA是否对胰腺癌治疗有益。目前正在进行两项前瞻性试验，以确定胆管内RFA在恶性梗阻中是否确实具有生存优势。
