Bolin B Levi, Alcorn Joseph L, Reynolds Anna R, Lile Joshua A, Rush Craig R
Department of Behavioral Science, University of Kentucky College of Medicine.
Exp Clin Psychopharmacol. 2016 Aug;24(4):214-28. doi: 10.1037/pha0000077.
Drug-discrimination procedures empirically evaluate the control that internal drug states exert over behavior. They provide a highly selective method to investigate the neuropharmacological underpinnings of the interoceptive effects of drugs. Historically, drug discrimination has been one of the most widely used assays in the field of behavioral pharmacology. Drug-discrimination procedures have also been adapted for use with humans and are conceptually similar to preclinical drug-discrimination techniques in that a behavior is differentially reinforced contingent on the presence or absence of a specific interoceptive drug stimulus. This review gives some general history and background concerning the major theoretical concepts and principles of drug-discrimination research as well as its relevance to substance-use disorders. This article also provides a procedural overview and discusses key methodological issues that must be considered when designing and conducting a human drug-discrimination study. Although drug discrimination is unequivocally one of the most sophisticated and useful behavioral assays to investigate the underlying neuropharmacology of drugs in vivo, enthusiasm for its use has steadily declined in the last decade and a half. We conclude by commenting on the current state of drug-discrimination research and suggest potential avenues for future drug-discrimination research. (PsycINFO Database Record
药物辨别程序通过实证研究内部药物状态对行为的控制作用。它们提供了一种高度选择性的方法来探究药物内感受效应的神经药理学基础。从历史上看，药物辨别一直是行为药理学领域应用最广泛的检测方法之一。药物辨别程序也已适用于人类，并且在概念上与临床前药物辨别技术相似，即一种行为会根据特定内感受性药物刺激的存在或不存在而得到差异性强化。这篇综述介绍了一些关于药物辨别研究的主要理论概念和原则的一般历史和背景，以及它与物质使用障碍的相关性。本文还提供了程序概述，并讨论了设计和开展人类药物辨别研究时必须考虑的关键方法学问题。尽管药物辨别无疑是研究体内药物潜在神经药理学最复杂且有用的行为检测方法之一，但在过去十五年中，其应用热度却在稳步下降。我们通过对药物辨别研究的现状进行评论来得出结论，并提出未来药物辨别研究的潜在途径。（PsycINFO数据库记录）
