Reynolds Anna R, Bolin B Levi, Stoops William W, Rush Craig R
Department of Psychology, University of Kentucky College of Arts and Sciences Departments of bBehavioral Science cPsychiatry, University of Kentucky College of Medicine, Lexington, KY 40536-0086, USA.
Behav Pharmacol. 2013 Sep;24(5-6):523-32. doi: 10.1097/FBP.0b013e328364505f.
The discriminative and subjective effects of drugs in humans are related, but the full extent of this relationship remains to be determined. To further explore this relationship, a retrospective analysis was conducted on data from six studies completed in our laboratory that used identical procedures. The relationship between the discriminative and subjective effects of a range of doses of D-amphetamine (i.e. 2.5-15 mg) was examined using correlational analyses. Significant correlations with discrimination performance were observed on 15 of 20 items from the Drug-Effect Questionnaire across a range of qualities [e.g. Pay For (a positive effect indicative of abuse potential) and Active (a stimulant-like effect)], but the magnitude of these relationships was modest (r<0.52). The current findings demonstrate that diverse subjective effects contribute to the discriminative effects of D-amphetamine and indicate that the former are a more practical means to assess the abuse potential of drugs. Although these procedures are fundamentally related in that they rely on the presence of an interoceptive drug state, they differ in the dimension(s) of the interoceptive effects that participants must quantify. The simultaneous use of drug discrimination and subjective effects may, therefore, reveal complimentary aspects of drug effects that underlie their potential for abuse.
药物在人体中的辨别性和主观效应是相关的，但这种关系的全貌仍有待确定。为了进一步探究这种关系，我们对在本实验室完成的六项采用相同程序的研究数据进行了回顾性分析。使用相关分析考察了一系列剂量的右旋苯丙胺（即2.5 - 15毫克）的辨别性和主观效应之间的关系。在《药物效应问卷》的20个项目中的15个项目上，观察到与辨别性能存在显著相关性，涉及一系列特质[例如“为其付出代价”（一种表明滥用潜力的积极效应）和“活跃”（一种类似兴奋剂的效应）]，但这些关系的强度适中（r < 0.52）。当前研究结果表明，多种主观效应促成了右旋苯丙胺的辨别性效应，并表明前者是评估药物滥用潜力的更实用手段。尽管这些程序在根本上是相关的，因为它们都依赖于内感受性药物状态的存在，但参与者必须量化的内感受性效应的维度有所不同。因此，同时使用药物辨别和主观效应可能会揭示药物效应中与滥用潜力相关的互补方面。
