Marrie Ruth Ann, Patten Scott, Tremlett Helen, Svenson Lawrence W, Wolfson Christina, Yu B Nancy, Elliott Lawrence, Profetto-McGrath Joanne, Warren Sharon, Leung Stella, Jette Nathalie, Bhan Virender, Fisk John D
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Mult Scler Relat Disord. 2016 Jul;8:86-92. doi: 10.1016/j.msard.2016.05.009. Epub 2016 May 11.
We aimed to estimate the incidence and prevalence of chronic lung disease (CLD), including asthma and chronic obstructive pulmonary disease, in the MS population versus a matched cohort from the general population.
We used population-based administrative data from four Canadian provinces to identify 44,452 persons with MS and 220,849 age-, sex- and geographically-matched controls aged 20 years and older. We employed a validated case definition to estimate the incidence and prevalence of CLD over the period 1995-2005, and used Poisson regression to assess temporal trends.
In 2005, the crude incidence of CLD per 100,000 persons was 806 (95%CI: 701-911) in the MS population, and 757 in the matched population (95%CI: 712-803). In 2005, the crude prevalence of CLD was 13.5% (95%CI: 13.1-14.0%) in the MS population, and 12.4% (95%CI: 12.3-12.6%) in the matched population. Among persons aged 20-44 years, the average annual incidence of CLD was higher in the MS population than in the matched population (RR 1.15; 95%CI: 1.02-1.30), but did not differ between populations for those aged ≥45 years. The incidence of CLD was stable, but the prevalence of CLD increased 60% over the study period.
CLD is relatively common in the MS population. The incidence of CLD has been stable over time, but the prevalence of CLD has increased. Among persons aged 20-44 years, CLD is more common in the MS population than in a matched population. Given the prevalence of CLD in the MS population, further attention to the effects of CLD on outcomes in MS and approaches to mitigating those effects are warranted.
我们旨在评估多发性硬化症（MS）人群与来自普通人群的匹配队列中慢性肺病（CLD）（包括哮喘和慢性阻塞性肺病）的发病率和患病率。
我们使用来自加拿大四个省份基于人群的管理数据，确定了44452例MS患者以及220849例年龄、性别和地理位置匹配的20岁及以上对照。我们采用经过验证的病例定义来估计1995 - 2005年期间CLD的发病率和患病率，并使用泊松回归评估时间趋势。
2005年，MS人群中每10万人CLD的粗发病率为806（95%CI：701 - 911），匹配人群中为757（95%CI：712 - 803）。2005年，MS人群中CLD的粗患病率为13.5%（95%CI：13.1 - 14.0%），匹配人群中为12.4%（95%CI：12.3 - 12.6%）。在20 - 44岁人群中，MS人群中CLD的年均发病率高于匹配人群（RR 1.15；95%CI：1.02 - 1.30），但在年龄≥45岁的人群中，不同人群之间无差异。CLD的发病率稳定，但在研究期间CLD的患病率增加了60%。
CLD在MS人群中相对常见。CLD的发病率随时间一直稳定，但患病率有所增加。在20 - 44岁人群中，CLD在MS人群中比在匹配人群中更常见。鉴于CLD在MS人群中的患病率，有必要进一步关注CLD对MS结局的影响以及减轻这些影响的方法。
