Milosevic Natasa, Milanovic Maja, Turkulov Vesna, Medić-Stojanoska Milica, Abenavoli Ludovico, Milic Natasa
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Rev Recent Clin Trials. 2016;11(3):227-37. doi: 10.2174/1574887111666160724184642.
Alcoholism is currently listed as the third leading cause of death. Chronic alcohol consumption brings serious medical complications like gastrointestinal, cardiovascular, musculoskeletal, respiratory system disorders. Liver can be seriously damage by alcohol misuse. Alcoholic Liver Disease (ALD) is the first important warning sign of alcohol abuse. Since effective therapies for ALD are still limited, natural products in the treatment of ALD become very important. In this regard, there have been done very few clinical trials with poor results. Silymarin, glycyrrhizin, garlic show some promising results in ALD patients while the in vivo and in vitro studies with green tee, quercetin and curcumin indicate positive effect on patients with ALD.
酗酒目前被列为第三大致死原因。长期饮酒会引发严重的医学并发症，如胃肠道、心血管、肌肉骨骼、呼吸系统紊乱。肝脏会因酒精滥用而受到严重损害。酒精性肝病（ALD）是酒精滥用的首个重要警示信号。由于针对ALD的有效治疗方法仍然有限，天然产物在ALD治疗中变得非常重要。在这方面，进行的临床试验很少，且结果不佳。水飞蓟宾、甘草甜素、大蒜在ALD患者中显示出一些有前景的结果，而对绿茶、槲皮素和姜黄素的体内和体外研究表明对ALD患者有积极作用。
