德国小蠊作为CTX-M-15超广谱β-内酰胺酶和OXA-48碳青霉烯酶产生肠杆菌科细菌储存宿主的首次报告——阿尔及利亚巴特纳大学医院
First Report of German Cockroaches (Blattella germanica) as Reservoirs of CTX-M-15 Extended-Spectrum-β-Lactamase- and OXA-48 Carbapenemase-Producing Enterobacteriaceae in Batna University Hospital, Algeria.
作者信息
Loucif Lotfi, Gacemi-Kirane Djamila, Cherak Zineb, Chamlal Naima, Grainat Nadia, Rolain Jean-Marc
机构信息
Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditérranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
Département de Biochimie, Faculté des Sciences, Université Badji Mokhtar Annaba, Annaba, Algeria.
出版信息
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6377-80. doi: 10.1128/AAC.00871-16. Print 2016 Oct.
Abstract
Here we report the isolation of extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae from German cockroaches caught in the burn unit of Batna University Hospital in Algeria. Nine of 12 isolates harbored the blaCTX-M-15 ESBL gene. One Enterobacter cloacae isolate belonging to sequence type 528 coexpressed the blaOXA-48, blaCTX-M-15, and blaTEM genes. Our findings indicate that cockroaches may be one of the most dangerous reservoirs for ESBL and carbapenemase producers in hospitals.
摘要
在此，我们报告从阿尔及利亚巴特纳大学医院烧伤科捕获的德国小蠊中分离出产超广谱β-内酰胺酶（ESBL）和碳青霉烯酶的肠杆菌科细菌。12株分离菌中有9株携带blaCTX-M-15 ESBL基因。一株属于序列型528的阴沟肠杆菌分离菌共表达blaOXA-48、blaCTX-M-15和blaTEM基因。我们的研究结果表明，蟑螂可能是医院中ESBL和碳青霉烯酶产生菌最危险的宿主之一。
相似文献
1
First Report of German Cockroaches (Blattella germanica) as Reservoirs of CTX-M-15 Extended-Spectrum-β-Lactamase- and OXA-48 Carbapenemase-Producing Enterobacteriaceae in Batna University Hospital, Algeria.
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6377-80. doi: 10.1128/AAC.00871-16. Print 2016 Oct.
2
First detection of an OXA-48-producing Enterobacter cloacae isolate from currency coins in Algeria.
J Glob Antimicrob Resist. 2020 Dec;23:162-166. doi: 10.1016/j.jgar.2020.09.003. Epub 2020 Sep 20.
3
Dominance of IMP-4-producing enterobacter cloacae among carbapenemase-producing Enterobacteriaceae in Australia.
Antimicrob Agents Chemother. 2015 Jul;59(7):4059-66. doi: 10.1128/AAC.04378-14. Epub 2015 Apr 27.
4
Migratory White Stork (Ciconia ciconia): A Potential Vector of the OXA-48-Producing Escherichia coli ST38 Clone in Algeria.
Microb Drug Resist. 2018 May;24(4):461-468. doi: 10.1089/mdr.2017.0174. Epub 2017 Oct 12.
5
Molecular typing and characterization of TEM, SHV, CTX-M, and CMY-2 β-lactamases in Enterobacter cloacae strains isolated in patients and their hospital environment in the west of Algeria.
Med Mal Infect. 2014 Apr;44(4):146-52. doi: 10.1016/j.medmal.2014.01.008. Epub 2014 Apr 14.
6
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
BMC Microbiol. 2019 Dec 4;19(1):272. doi: 10.1186/s12866-019-1629-x.
7
High rate of faecal carriage of extended-spectrum β-lactamase and OXA-48 carbapenemase-producing Enterobacteriaceae at a university hospital in Morocco.
Clin Microbiol Infect. 2014 Apr;20(4):350-4. doi: 10.1111/1469-0691.12325. Epub 2013 Aug 9.
8
High prevalence of CTX-M-15 and first report of CTX-M-3, CTX-M-22, CTX-M-28 and plasmid-mediated AmpC beta-lactamase producing Enterobacteriaceae causing urinary tract infections in Bosnia and Herzegovina in hospital and community settings.
J Infect Chemother. 2015 May;21(5):363-9. doi: 10.1016/j.jiac.2015.01.003. Epub 2015 Jan 9.
9
MALDI-TOF MS as a Tool To Detect a Nosocomial Outbreak of Extended-Spectrum-β-Lactamase- and ArmA Methyltransferase-Producing Enterobacter cloacae Clinical Isolates in Algeria.
Antimicrob Agents Chemother. 2015 Oct;59(10):6477-83. doi: 10.1128/AAC.00615-15. Epub 2015 Aug 3.
10
Prevalence and characterization of extended spectrum beta-lactamase-producing Enterobacter cloacae strains in Algeria.
J Infect Dev Ctries. 2013 Nov 15;7(11):804-11. doi: 10.3855/jidc.3127.
引用本文的文献
1
Pathogens of Medical Importance Identified in Hospital-Collected Cockroaches: A Systematic Review.
Microorganisms. 2025 Feb 4;13(2):337. doi: 10.3390/microorganisms13020337.
2
Extended spectrum and metalo beta lactamase producing gram negative bacterial pathogens from cockroaches collected at hospital, Southern Ethiopia.
Antimicrob Resist Infect Control. 2024 Aug 13;13(1):87. doi: 10.1186/s13756-024-01442-0.
3
The Importance of Carbapenemase-Producing Enterobacterales in African Countries: Evolution and Current Burden.
Antibiotics (Basel). 2024 Mar 24;13(4):295. doi: 10.3390/antibiotics13040295.
4
Dissemination of Carbapenemases and MCR-1 Producing Gram-Negative Bacteria in Aquatic Environments in Batna, Algeria.
Antibiotics (Basel). 2022 Sep 27;11(10):1314. doi: 10.3390/antibiotics11101314.
5
OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline.
Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0021622. doi: 10.1128/aac.00216-22. Epub 2022 Jul 20.
6
First Report of Extended-Spectrum β-Lactamase () and Colistin Resistance Gene in E. coli of Lineage ST648 from Cockroaches in Tunisia.
Microbiol Spectr. 2022 Apr 27;10(2):e0003621. doi: 10.1128/spectrum.00036-21. Epub 2022 Mar 1.
7
Household cockroaches carry CTX-M-15-, OXA-48- and NDM-1-producing enterobacteria, and share beta-lactam resistance determinants with humans.
BMC Microbiol. 2019 Dec 4;19(1):272. doi: 10.1186/s12866-019-1629-x.
8
Nosocomial Pathogens: An In-Depth Analysis of the Vectorial Potential of Cockroaches.
Trop Med Infect Dis. 2019 Jan 17;4(1):14. doi: 10.3390/tropicalmed4010014.
9
Role of Institut Hospitalo-Universitaire Méditerranée Infection in the surveillance of resistance to antibiotics and training of students in the Mediterranean basin and in African countries.
New Microbes New Infect. 2018 Jun 14;26:S52-S64. doi: 10.1016/j.nmni.2018.06.001. eCollection 2018 Nov.
10
Multispecies and Clonal Dissemination of OXA-48 Carbapenemase in From Companion Animals in Germany, 2009-2016.
Front Microbiol. 2018 Jun 14;9:1265. doi: 10.3389/fmicb.2018.01265. eCollection 2018.
本文引用的文献
1
First Detection of VIM-4-Producing Pseudomonas aeruginosa and OXA-48-Producing Klebsiella pneumoniae in Northeastern (Annaba, Skikda) Algeria.
Microb Drug Resist. 2017 Apr;23(3):335-344. doi: 10.1089/mdr.2016.0032. Epub 2016 Jun 17.
2
Beta-lactamases in Enterobacteriaceae infections in children.
J Infect. 2016 Jul 5;72 Suppl:S41-9. doi: 10.1016/j.jinf.2016.04.021. Epub 2016 May 11.
3
First outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Constantine, Algeria.
Int J Antimicrob Agents. 2015 Dec;46(6):725-7. doi: 10.1016/j.ijantimicag.2015.08.005. Epub 2015 Sep 9.
4
Rapid identification of carbapenemase-producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii using a modified Carba NP test.
New Microbes New Infect. 2015 Jul 10;7:89-93. doi: 10.1016/j.nmni.2015.07.001. eCollection 2015 Sep.
5
New Delhi metallo-β-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya.
Libyan J Med. 2015 Aug 19;10(1):29206. doi: 10.3402/ljm.v10.29206. eCollection 2015.
6
TEM and SHV Genes in Klebsiella pneumoniae Isolated from Cockroaches and Their Antimicrobial Resistance Pattern.
Osong Public Health Res Perspect. 2015 Feb;6(1):3-8. doi: 10.1016/j.phrp.2014.10.011. Epub 2014 Dec 23.
7
Carbapenemase-producing Enterobacteriaceae.
Semin Respir Crit Care Med. 2015 Feb;36(1):74-84. doi: 10.1055/s-0035-1544208. Epub 2015 Feb 2.
8
Emergence of OXA-48-producing Escherichia coli clone ST38 in fowl.
Antimicrob Agents Chemother. 2015 Jan;59(1):745-6. doi: 10.1128/AAC.03552-14. Epub 2014 Oct 27.
9
Development of a multiplex real-time PCR for the rapid detection of the predominant beta-lactamase genes CTX-M, SHV, TEM and CIT-type AmpCs in Enterobacteriaceae.
PLoS One. 2014 Jul 17;9(7):e100956. doi: 10.1371/journal.pone.0100956. eCollection 2014.
10
Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries.
Biomed Res Int. 2014;2014:305784. doi: 10.1155/2014/305784. Epub 2014 May 13.
Zotero 插件