Xu Yi-Xin, Xiang Zhao-Bao, Jin Yong-Sheng, Xu Wen, Sun Lian-Na, Chen Wan-Sheng, Chen Hai-Sheng
School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
School of Pharmacy, Shanghai University of Medical & Health Sciences, Shanghai, 200237, P. R. China.
Chem Biodivers. 2016 Nov;13(11):1454-1459. doi: 10.1002/cbdv.201500518. Epub 2016 Nov 10.
A newly discovered triterpenoid, (2α,3β)-2,3,23-trihydroxyurs-13(18)-en-28-oic acid (1), along with twelve known compounds (2 - 13), were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). Their chemical structures were determined by 1D- and 2D-NMR spectra and mass spectrometry (MS). The crude extracts and six main constituents (8 - 13) were tested for cytochrome P450 (CYPs) enzyme inhibitory activity. The results showed that, except for compound 8, compounds 9 - 13 had different inhibitory effects on the cytochrome P450 (CYPs) enzyme, and compound 9 significantly inhibited the catalytic activities of CYP3A4 to < 10% of its control activities.
从中华猕猴桃（猕猴桃科）根部分离得到一种新发现的三萜类化合物，(2α,3β)-2,3,23-三羟基乌苏-13(18)-烯-28-酸（1），以及12种已知化合物（2 - 13）。通过一维和二维核磁共振光谱以及质谱（MS）确定了它们的化学结构。对粗提物和六种主要成分（8 - 13）进行了细胞色素P450（CYPs）酶抑制活性测试。结果表明，除化合物8外，化合物9 - 13对细胞色素P450（CYPs）酶有不同的抑制作用，化合物9显著抑制CYP3A4的催化活性，使其降至对照活性的<10%。
