急性乙醛和乙醇中毒后大鼠肝脏中的线粒体和微粒体脂质过氧化作用。

Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication.

作者信息

Uysal M, Ozdemirler G, Kutalp G, Oz H

机构信息

Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.

出版信息

J Appl Toxicol. 1989 Jun;9(3):155-8. doi: 10.1002/jat.2550090304.

DOI:10.1002/jat.2550090304

PMID:2745923

Abstract

The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.

摘要

在给予大鼠相应毒性剂量后，比较乙醛和乙醇处理对肝脏脂质过氧化的影响。将Wistar大鼠腹腔注射单剂量乙醛（0.5 g/kg）或乙醇（5 g/kg）。处理后1/2、1、2、4、6、9、12和24小时处死动物。结果表明，乙醛与乙醇一样，会刺激肝脏脂质过氧化，并且还会选择性地影响肝脏线粒体。