Rovira Aleix, Tornero Jordi, Oliva Marc, Taberna Miren, Montal Robert, Nogues Julio, Farre Anna, Lares Henry, Navarro Valenti, Mari Antoni, Vinals Joan Maria, Lozano Alicia, Mesia Ricard, Manos Manel
Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
Department of Medical Oncology, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
Head Neck. 2017 Jan;39(1):116-121. doi: 10.1002/hed.24549. Epub 2016 Jul 26.
The purpose of this study was to describe the results and complications of primary site salvage surgery after head and neck squamous cell carcinoma (HNSCC) treated with bioradiotherapy.
We conducted a retrospective chart review of 268 patients treated with bioradiotherapy between March 2006 and December 2013 at the Hospital Universitari de Bellvitge-ICO.
Fifty-nine patients developed local recurrence or had residual disease with a 1-year and 3-year overall survival of 47% and 15.4%, respectively. Salvage surgery was feasible in 22 patients (37.3%). There were 16 complications in these 22 patients (72.7%), 11 (50%) of which were major. Bilateral neck dissection was identified as a risk factor for complications.
Salvage surgery after bioradiotherapy is associated with a high rate of complications. Neck dissection seems to be related to an increased rate of complications with no survival improvement. © 2016 Wiley Periodicals, Inc. Head Neck 39: 116-121, 2017.
本研究旨在描述生物放疗治疗头颈部鳞状细胞癌（HNSCC）后原发部位挽救性手术的结果及并发症。
我们对2006年3月至2013年12月间在贝尔维特奇大学医院 - ICO接受生物放疗的268例患者进行了回顾性病历审查。
59例患者出现局部复发或有残留病灶，其1年和3年总生存率分别为47%和15.4%。22例患者（37.3%）可行挽救性手术。这22例患者中有16例发生并发症（72.7%），其中11例（50%）为严重并发症。双侧颈清扫被确定为并发症的一个危险因素。
生物放疗后的挽救性手术并发症发生率较高。颈清扫似乎与并发症发生率增加相关，且未改善生存率。©2016威利期刊公司。《头颈》39: 116 - 121, 2017。
