Huang Feifei, Zhang Ji, Wang Huijun, Wang Zhihong, Zhang Jiguo, Du Wenwen, Su Chang, Jiang Hongru, Jia Xiaofang, Zhai Fengying, Zhang Bing
Wei Sheng Yan Jiu. 2016 May;45(3):383-7.
To examine the longitudinal association between dietary cholesterol intake and stroke incidence in Chinese adults.
The data were from 5833 non-stroke participants aged 30-98 in 1997 and more than one repeated measurements in the following five waves (2000, 2004, 2006, 2009 and 2011) of the China Health and Nutrition Survey. 5805 participants were included eventually after removing those with abnormal dietary cholesternul intake. Dietary cholesterol and energy intake was assessed with 3 d - 24 h dietary recalls in all the waves. Self-reported hypertension, diabetes mellitus, alcohol drinking, smoking, and standardized measurement of waist circumstance were collected also. Time-dependent Cox proportional hazard regression models were constructed to estimate relative risks (RR) with 95% confidence intervals (CI).
During the mean 11. 3 years follow-up, 198 stroke events of 5805 participants were ascertained. The quintiles dietary cholesterol intake were 70.0, 146.9, 218.3, 297.8 and 425.9 mg/d. After adjusted for potential confounders, the time-dependent cholesterol intake, baseline cholesterol intake and the mean cholesterol intake during 1997-2011 were insignificantly associated with stroke. The relative risks and 95% confidence intervals were 1. 000 (0.999 - 1.001), 1.000 (0.999 - 1.001 ) and 0.999 (0.998 - 1.001) respectively. The cholesterol intake quintiles were insignificantly associated with stroke incidence. The relative risks and 95% confidence intervals versus lowest quintile were 0.812 (0.504 - 1.310), 0.644 (0.389 - 1.066) 0.913 (0.576 - 1.446) and 0.692 (0.416 - 1.152) respectively.
Effect of dietary cholesterol intake on stroke incidence might was insignificant in Chinese adults.
研究中国成年人饮食中胆固醇摄入量与中风发病率之间的纵向关联。
数据来自1997年5833名年龄在30 - 98岁的非中风参与者，以及随后五轮（2000年、2004年、2006年、2009年和2011年）中国健康与营养调查中的多次重复测量。在剔除饮食中胆固醇摄入量异常者后，最终纳入5805名参与者。所有轮次均通过3天-24小时饮食回顾法评估饮食中的胆固醇和能量摄入量。还收集了自我报告的高血压、糖尿病、饮酒、吸烟情况以及腰围的标准化测量值。构建时间依存性Cox比例风险回归模型以估计相对风险（RR）及95%置信区间（CI）。
在平均11.3年的随访期间，5805名参与者中确定了198例中风事件。饮食中胆固醇摄入量的五分位数分别为70.0、146.9、218.3、297.8和425.9毫克/天。在对潜在混杂因素进行调整后，时间依存性胆固醇摄入量、基线胆固醇摄入量以及1997 - 2011年期间的平均胆固醇摄入量与中风的关联均不显著。相对风险及95%置信区间分别为1.000（0.999 - 1.001）、1.000（0.999 - 1.001）和0.999（0.998 - 1.001）。胆固醇摄入量五分位数与中风发病率的关联不显著。与最低五分位数相比，相对风险及95%置信区间分别为0.812（0.504 - 1.310）、0.644（0.389 - 1.066）、0.913（0.576 - 1.446）和0.692（0.416 - 1.152）。
饮食中胆固醇摄入量对中国成年人中风发病率的影响可能不显著。
