Titova Olga E, Lindberg Eva, Elmståhl Sölve, Lind Lars, Schiöth Helgi B, Benedict Christian
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Respiratory Medicine, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Neurobiol Aging. 2016 Sep;45:23-29. doi: 10.1016/j.neurobiolaging.2016.05.007. Epub 2016 May 14.
Shift work has been proposed to promote cognitive disturbances in humans; however, conflicting evidence is also present. By using data from 7143 middle-aged and elderly humans (45-75 years) who participated in the Swedish EpiHealth cohort study, the present analysis sought to investigate whether self-reported shift work history would be associated with performance on the trail making test (TMT). The TMT has been proposed to be a useful neuropsychological tool to evaluate humans' executive cognitive function, which is known to decrease with age. After adjustment for potential confounders (e.g., age, education, and sleep duration), it was observed that current and recent former shift workers (worked shifts during the past 5 years) performed worse on the TMT than nonshift workers. In contrast, performance on the TMT did not differ between past shift workers (off from shift work for more than 5 years) and nonshift workers. Collectively, our results indicate that shift work history is linked to poorer performance on the TMT in a cohort of middle-aged and elderly humans.
轮班工作被认为会导致人类认知障碍；然而，也存在相互矛盾的证据。通过使用来自7143名中年和老年人（45 - 75岁）的数据，这些人参与了瑞典EpiHealth队列研究，本分析旨在调查自我报告的轮班工作史是否与连线测验（TMT）的表现相关。TMT被认为是一种有用的神经心理学工具，用于评估人类的执行认知功能，而执行认知功能已知会随着年龄增长而下降。在对潜在混杂因素（如年龄、教育程度和睡眠时间）进行调整后，观察到当前和近期的前轮班工作者（在过去5年中从事轮班工作）在TMT上的表现比非轮班工作者更差。相比之下，过去的轮班工作者（停止轮班工作超过5年）和非轮班工作者在TMT上的表现没有差异。总体而言，我们的结果表明，在一组中年和老年人中，轮班工作史与TMT表现较差有关。
