Schmidt Sissel Ida, Knudsen Matias Jul, Barnkob Helle Bogetofte, Meyer Morten
Ugeskr Laeger. 2016 Jul 18;178(29).
Research into the causes of neurodegenerative diseases like Parkinson's- and Alzheimer's disease has long been hampered by the lack of access to live disease-afflicted neurons for in vitro studies. The introduction of induced pluripotent stem (iPS) cells has made such studies possible. iPS cells can be reprogrammed from somatic patient-derived cells (e.g. skin cells) and differentiated into any cell type of the body. This allows for the production of neurons, which have the genetic background of the patients and show disease-relevant phenotypes.
长期以来，帕金森病和阿尔茨海默病等神经退行性疾病的病因研究一直受到阻碍，因为缺乏用于体外研究的活体患病神经元。诱导多能干细胞（iPS细胞）的引入使此类研究成为可能。iPS细胞可以从患者来源的体细胞（如皮肤细胞）重新编程而来，并分化为身体的任何细胞类型。这使得能够产生具有患者遗传背景并表现出与疾病相关表型的神经元。
