Ståhle-Bäckdahl M, Hägermark O, Lins L E, Törring O, Hilliges M, Johansson O
Department of Dermatology, Karolinska Sjukhuset, Stockholm, Sweden.
J Intern Med. 1989 Jun;225(6):411-5. doi: 10.1111/j.1365-2796.1989.tb00104.x.
Secondary hyperparathyroidism has been suggested as a cause of itching in chronic renal failure. The aim of the present study was to evaluate the possible role of parathyroid hormone (PTH) in pruritus affecting patients undergoing maintenance haemodialysis. In agreement with our previous findings, patients with pruritus had significantly (P less than 0.01) higher serum levels of PTH fragment 53-68 (m-PTH53-68) than patients without pruritus, 47.7 +/- 40.0 and 23.4 +/- 17.1 micrograms l-1 respectively. Serum concentrations of other substances including calcium, phosphate and magnesium did not differ between the two groups of patients. Intradermal injections of human PTH1-34 and PTH44-68 failed to evoke any acute or delayed cutaneous reactions in either patients or controls. Immunohistochemical investigations of skin biopsies from uraemic patients using several different antibodies against PTH were negative. Thus, the present results do not support PTH as a peripheral mediator of uraemic itching.
继发性甲状旁腺功能亢进被认为是慢性肾衰竭瘙痒的一个原因。本研究的目的是评估甲状旁腺激素（PTH）在影响维持性血液透析患者瘙痒中的可能作用。与我们之前的研究结果一致，瘙痒患者的血清PTH片段53 - 68（m - PTH53 - 68）水平显著高于无瘙痒患者（P < 0.01），分别为47.7±40.0和23.4±17.1微克/升。两组患者中包括钙、磷和镁在内的其他物质的血清浓度没有差异。对患者和对照组进行人PTH1 - 34和PTH44 - 68的皮内注射均未引起任何急性或延迟性皮肤反应。使用几种不同的抗PTH抗体对尿毒症患者皮肤活检进行免疫组织化学研究结果为阴性。因此，目前的结果不支持PTH作为尿毒症瘙痒的外周介质。
