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Failing Heart and Starving Brain: Ketone Bodies to the Rescue.

作者信息

Taegtmeyer Heinrich

机构信息

From McGovern Medical School at The University of Texas Health Science Center at Houston, Department of Internal Medicine, Division of Cardiology, Houston, TX.

出版信息

Circulation. 2016 Jul 26;134(4):265-6. doi: 10.1161/CIRCULATIONAHA.116.022141.

DOI:10.1161/CIRCULATIONAHA.116.022141

PMID:27462050

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6818087/

Abstract

摘要

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本文引用的文献

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27.

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation. 2016 Feb 23;133(8):706-16. doi: 10.1161/CIRCULATIONAHA.115.017545. Epub 2016 Jan 27.

Ketoacids? Good medicine?

Trans Am Clin Climatol Assoc. 2003;114:149-61; discussion 162-3.

Utilization of energy-providing substrates in the isolated working rat heart.

Biochem J. 1980 Mar 15;186(3):701-11. doi: 10.1042/bj1860701.

Starvation in man.

N Engl J Med. 1970 Mar 19;282(12):668-75. doi: 10.1056/NEJM197003192821209.

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相似文献

Failing Heart and Starving Brain: Ketone Bodies to the Rescue.

Circulation. 2016 Jul 26;134(4):265-6. doi: 10.1161/CIRCULATIONAHA.116.022141.

Ketone metabolism in the failing heart.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158813. doi: 10.1016/j.bbalip.2020.158813. Epub 2020 Sep 10.

Metabolism of ketone bodies by the brain.

Annu Rev Med. 1973;24:271-80. doi: 10.1146/annurev.me.24.020173.001415.

Cardiac Energy Metabolism in Heart Failure.

Circ Res. 2021 May 14;128(10):1487-1513. doi: 10.1161/CIRCRESAHA.121.318241. Epub 2021 May 13.

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27.

[Potential implications of ketone body metabolism changes and ketogenic therapy in the treatment of heart failure].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023 Jul;35(7):769-772. doi: 10.3760/cma.j.cn121430-20221008-00891.

The regulation of the release of ketone bodies by the liver.

Adv Enzyme Regul. 1966;4:339-54. doi: 10.1016/0065-2571(66)90027-6.

The glucose-fatty acid-ketone body cycle. Role of ketone bodies as respiratory substrates and metabolic signals.

Br J Anaesth. 1981 Feb;53(2):131-6. doi: 10.1093/bja/53.2.131.

Fatty acid, cholesterol, and acetoacetate biosynthesis in liver homogenates from normal and starved guinea pigs.

Can J Biochem Physiol. 1960 Jul;38:635-42.

Cardiac ketone body metabolism.

Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165739. doi: 10.1016/j.bbadis.2020.165739. Epub 2020 Feb 19.

引用本文的文献

A ketogenic-promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation.

Physiol Rep. 2025 Mar;13(6):e70208. doi: 10.14814/phy2.70208.

Molecular Pathways in Diabetic Cardiomyopathy and the Role of Anti-hyperglycemic Drugs Beyond Their Glucose Lowering Effect.

J Lipid Atheroscler. 2025 Jan;14(1):54-76. doi: 10.12997/jla.2025.14.1.54. Epub 2024 Nov 28.

Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations.

Front Pharmacol. 2024 Oct 24;15:1463381. doi: 10.3389/fphar.2024.1463381. eCollection 2024.

Roles of non-coding RNA in diabetic cardiomyopathy.

Cardiovasc Diabetol. 2024 Jun 29;23(1):227. doi: 10.1186/s12933-024-02252-9.

Circulating ketone bodies and mortality in heart failure: a community cohort study.

Front Cardiovasc Med. 2024 Jan 24;11:1293901. doi: 10.3389/fcvm.2024.1293901. eCollection 2024.

Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy.

Metabolites. 2023 Aug 9;13(8):932. doi: 10.3390/metabo13080932.

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Metabolites. 2022 Jun 22;12(7):579. doi: 10.3390/metabo12070579.

Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF.

Circulation. 2022 Sep 13;146(11):808-818. doi: 10.1161/CIRCULATIONAHA.122.060402. Epub 2022 May 23.

The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms.

Front Med (Lausanne). 2021 Jun 30;8:695792. doi: 10.3389/fmed.2021.695792. eCollection 2021.

Mitochondrial Bioenergetics and Dynamism in the Failing Heart.

Life (Basel). 2021 May 12;11(5):436. doi: 10.3390/life11050436.

本文引用的文献

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27.

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Circulation. 2016 Feb 23;133(8):706-16. doi: 10.1161/CIRCULATIONAHA.115.017545. Epub 2016 Jan 27.

Ketoacids? Good medicine?

Trans Am Clin Climatol Assoc. 2003;114:149-61; discussion 162-3.

Utilization of energy-providing substrates in the isolated working rat heart.

Biochem J. 1980 Mar 15;186(3):701-11. doi: 10.1042/bj1860701.

Starvation in man.

N Engl J Med. 1970 Mar 19;282(12):668-75. doi: 10.1056/NEJM197003192821209.

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Failing Heart and Starving Brain: Ketone Bodies to the Rescue.

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