鸡胚模型中米糠油的安全性评估。
Safety assessment of rice bran oil in a chicken embryo model.
作者信息
Araghi Atefeh, Seifi Saeed, Sayrafi Reza, Sadighara Parisa
机构信息
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.
Department of Environmental Health Engineer, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Avicenna J Phytomed. 2016 May-Jun;6(3):351-6.
OBJECTIVE
Rice Bran Oil (RBO) is extracted from the outer layer of rice. Little information is available regarding its safety. The present study was conducted to assess its safety in chicken embryo model.
MATERIALS AND METHODS
RBO was injected on day 4 of incubation of chickens. The tissues and serum samples were collected. Oxidative stress parameters in the liver, kidney and brain and biochemical parameters of serum were measured. The deformities were also investigated.
RESULTS
The changes in the liver enzymes activity were not statistically significant. There was significant decrease and increase in lipid peroxidation and glutathione level, respectively. It is suggested that RBO is a natural antioxidant source. Low-density lipoprotein cholesterol (LDL) also decreased. No abnormal findings were observed in the chickens.
CONCLUSION
No toxic effect was observed following RBO administration in chicken embryos. This study showed that RBO is not a safety concern.
目的
米糠油（RBO）是从米的外层提取的。关于其安全性的信息很少。本研究旨在评估其在鸡胚模型中的安全性。
材料与方法
在鸡孵化的第4天注射米糠油。收集组织和血清样本。测量肝脏、肾脏和大脑中的氧化应激参数以及血清的生化参数。还对畸形情况进行了调查。
结果
肝酶活性的变化无统计学意义。脂质过氧化和谷胱甘肽水平分别显著降低和升高。提示米糠油是一种天然抗氧化剂来源。低密度脂蛋白胆固醇（LDL）也有所下降。在鸡中未观察到异常发现。
结论
在鸡胚中给予米糠油后未观察到毒性作用。本研究表明米糠油不存在安全问题。
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