Fahy J, Glynn D, Hutchinson M
Department of Neurology, Adelaide Hospital, Dublin, Ireland.
J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):786-7. doi: 10.1136/jnnp.52.6.786.
The Cambridge Low Contrast Gratings (CLCG) were used to assess contrast sensitivity (CS) in 39 patients with clinically definite multiple sclerosis and 60 control subjects. CS was determined in both horizontal and vertical orientations and compared with visual evoked responses (VERs) in the same populations. Only 33% of patients had abnormal CS whereas 82% had abnormal VERs. There was no correlation between the degree of abnormalities in CS and VERs. There was no significant difference between CS determined in the vertical and horizontal orientation; however, examination in the vertical orientation increased the number of abnormalities detected by 2 (5%). We conclude that although CS, using the CLCG, is abnormal in a proportion of multiple sclerosis patients its detection is not clinically useful and is insensitive as a measure of subclinical optic neuropathy in multiple sclerosis.
采用剑桥低对比度光栅（CLCG）对39例临床确诊的多发性硬化症患者和60名对照者进行对比敏感度（CS）评估。在水平和垂直方向均测定了CS，并与同一人群的视觉诱发电位（VERs）进行比较。只有33%的患者CS异常，而82%的患者VERs异常。CS和VERs的异常程度之间没有相关性。垂直和水平方向测定的CS之间没有显著差异；然而，垂直方向检查使检测到的异常数量增加了2例（5%）。我们得出结论，虽然使用CLCG测定的CS在一部分多发性硬化症患者中异常，但其检测在临床上并无用处，作为多发性硬化症亚临床视神经病变的一项指标并不敏感。
