Korpela H, Kinnunen E, Juntunen J, Kumpulainen J, Koskenvuo M
Department of Physiology, University of Oulu, Finland.
J Neurol Sci. 1989 Jun;91(1-2):79-84. doi: 10.1016/0022-510x(89)90077-4.
Serum selenium concentration, glutathione peroxidase activity and lipid peroxides were determined in patients with multiple sclerosis (MS). The series consisted of 13 same-sexed twin pairs derived from the Finnish Twin Cohort of 15,815 pairs. Fourteen subjects had a definite and 1 a probable MS, and their 11 co-twins showed no evidence of central nervous system disease. No statistical differences were observed, but the 3 patients with active progressive MS had a higher mean level of lipid peroxides than the rest of the patients. We suggest that serum lipid peroxidation may be involved in the activity of MS.
对多发性硬化症（MS）患者的血清硒浓度、谷胱甘肽过氧化物酶活性和脂质过氧化物进行了测定。该系列包括13对同性双胞胎，来自芬兰双胞胎队列的15815对双胞胎。14名受试者患有明确的MS，1名可能患有MS，他们的11名同卵双胞胎没有中枢神经系统疾病的迹象。未观察到统计学差异，但3例活动性进展型MS患者的脂质过氧化物平均水平高于其他患者。我们认为血清脂质过氧化可能与MS的活动有关。
